@article {1499650,
	title = {Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study},
	journal = {Alzheimers Res Ther},
	volume = {12},
	number = {1},
	year = {2020},
	month = {2020 Apr 06},
	pages = {38},
	abstract = {BACKGROUND: Inflammatory processes have been shown to play a role in dementia. To understand this role, we selected two anti-inflammatory drugs (methotrexate and sulfasalazine) to study their association with dementia risk.

METHODS: A retrospective matched case-control study of patients over 50 with rheumatoid arthritis (486 dementia cases and 641 controls) who were identified from electronic health records in the UK, Spain, Denmark and the Netherlands. Conditional logistic regression models were fitted to estimate the risk of dementia.

RESULTS: Prior methotrexate use was associated with a lower risk of dementia (OR 0.71, 95\% CI 0.52-0.98). Furthermore, methotrexate use with therapy longer than 4 years had the lowest risk of dementia (odds ratio 0.37, 95\% CI 0.17-0.79). Sulfasalazine use was not associated with dementia (odds ratio 0.88, 95\% CI 0.57-1.37).

CONCLUSIONS: Further studies are still required to clarify the relationship between prior methotrexate use and duration as well as biological treatments with dementia risk.},
	issn = {1758-9193},
	doi = {10.1186/s13195-020-00606-5},
	author = {Newby, Danielle and Prieto-Alhambra, Daniel and Duarte-Salles, Talita and Ansell, David and Pedersen, Lars and van der Lei, Johan and Mosseveld, Mees and Rijnbeek, Peter and James, Glen and Alexander, Myriam and Egger, Peter and Podhorna, Jana and Stewart, Robert and Perera, Gayan and Avillach, Paul and Grosdidier, Sol{\`e}ne and Lovestone, Simon and Nevado-Holgado, Alejo J}
}
