Current

NHLBI Cure Sickle Cell Initiative

The Cure Sickle Cell Initiative is a collaborative, patient-focused research effort designed to accelerate promising genetic therapies to cure sickle cell disease. The Initiative considers non-traditional ways to advance research and brings together the sickle cell disease (SCD) community—patients, advocates, caregivers, providers, researchers, industry, and others.

NHLBI BioDataCatalyst

NHLBI BioData Catalyst is a cloud-based platform providing tools, applications, and workflows in secure workspaces. By increasing access to NHLBI datasets and innovative data analysis capabilities, BioData Catalyst accelerates efficient biomedical research that drives discovery and scientific advancement, leading to novel diagnostic tools, therapeutics, and prevention strategies for heart, lung, blood, and sleep disorders.

Though the primary goal of the BioData Catalyst project is to build a data science ecosystem, at its core, this is a people-centric endeavor. BioData...

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Post-Doctoral Fellowship at Harvard-MIT Center for Regulatory Science, Harvard Program in Therapeutic Science - Boston MA

The Harvard Program in Therapeutic Science (HiTS) invites applications for a fellowship position at the Harvard-MIT Center for Regulatory Science. The fellow will work with a multidisciplinary team to develop and evaluate novel computational methods to support automated detection of drug-drug interactions in large and disparate healthcare datasets.

 

ABOUT THE FELLOWSHIP PROGRAM

The Harvard-MIT Center for Regulatory Science is a partnership...

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NIH/NCATS Global Rare Diseases Patient Registry i2b2/tranSMART Data Repository

NIH/NCATS

Co-PI  Total $2.4M  (PI: Isaac Kohane)

The integration of clinical and biomedical data hosted in multiple distributed repositories is confonted by two significant challenges: 1) correctly linking information pertaining to the same patient across repositories, for example, linking lab results data with bedside observations data; and 2) making data available for analysis at different locations across a collaboration network. These problems are exacerbated in the case of rare diseases research, given the very limited availability of data sets and...

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BCH Precision Link - Genomics Research and Innovation Network (GRIN)

Boston Children's Hospital (BCH), Cincinnati Children's Hospital Medical Center (CCHMC), Children's Hospital of Philadelphia (CHOP)

Co-Investigator BCH  Total: $6M  PI BCH: Ken Mandl

To accelerate genomic discovery, collaboration, and improved clinical outcomes, research leaders at Boston Children's Hospital (BCH), Cincinnati Children's Hospital Medical Center (CCHMC), and Children's Hospital of Philadelphia (CHOP) have come together to propose the creation of the Genomics Research and Innovation Network (GRIN). 

Four major potential uses...

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Phelan-McDermid Syndrome Data Network (PMS_DN) - Phase II

PCORI - PPRN

Co-PI ($1.2 million) Total 1.6K (PI: Megan O'Boyle)

To collect all available patient data from Phelan-McDermid Syndrome (PMS) patients to make meaningful, well-annotated clinical data available to researchers and to share insights with members of the PCORI network.

TranSMART platform based on i2b2 is being used to integrate Patient Reported Outcomes and Knowledge extracted from Clinical Notes using cTAKES